NEW! IN PRESS:
Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D.
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
Cell. 2009 Feb 6;136(3):420-34.
Abstract
For an up to the moment current listing of publications, please visit PubMed lab listings.
2009
Panier S, Durocher D.
Regulatory ubiquitylation in response to DNA double-strand breaks.
DNA Repair. 2009 Apr 5;8(4):436-43.
Abstract
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
Cell. 2009 Feb 6;136(3):435-46.
Abstract
Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D.
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
Cell. 2009 Feb 6;136(3):420-34.
Abstract
2008
Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F.
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol Cell. 2008 Oct 24;32(2):259-75.
Dixon SJ, Fedyshyn Y, Koh JL, Prasad TS, Chahwan C, Chua G, Toufighi K, Baryshnikova A, Hayles J, Hoe KL, Kim DU, Park HO, Myers CL, Pandey A, Durocher D, Andrews BJ, Boone C.
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16653-8.
Addinall SG, Downey M, Yu M, Zubko M, Dewar J, Leake A, Hallinan J, Shaw O, James K, Wilkinson DJ, Wipat A, Durocher D, Lydall D.
A Genome-wide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae.
Genetics 2008 Oct 9. [Epub ahead of print]
Nakada S, Chen GI, Gingras AC, Durocher D.
PP4 is a gammaH2AX phosphatase required for recovery from the DNA damage checkpoint.
EMBO Rep. 2008 Oct;9(10):1019-26. Epub 2008 Aug 29.
Yeung M, Durocher D.
Engineering a DNA damage response without DNA damage.
Genome Biol. 2008;9(7):227.
Zhang W, Durocher D.
Dun1 counts on Rad53 to be turned on.
Mol Cell. 2008 Jul 11;31(1):1-2.
Fu Y, Zhu Y, Zhang K, Yeung M, Durocher D, Xiao W.
Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.
Cell. 2008 May 16;133(4):601-11.
Macrae CJ, McCulloch RD, Ylanko J, Durocher D, Koch CA.
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.
DNA Repair (Amst). 2008 Feb 1;7(2):292-302.
2007
Kolas NK, Chapman JR , Nakada S, Ylanko Y, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase.
Science [DOI: 10.1126/science.1150034]
Abstract
Science Reprint
Kanellis P, Gagliardi M, Banath JP, Szilard RK, Nakada S, Galicia S, Sweeney FD, Cabelof DC, Olive PL, Durocher D.
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.
PLoS Genet. 2007 Aug 10;3(8):e134.
PubMed abstract
Reprint
2006
Woolstencroft RN, Beilharz TH, Cook MA, Preiss T, Durocher D, Tyers M.
Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length.
J Cell Sci. 2006 Dec 15;119(Pt 24):5178-92.
PubMed abstract
Szilard RK, Durocher D.
Telomere protection: an act of God.
Curr Biol. 2006 Jul 25;16(14):R544-6.
PubMed abstract
Downey M, Durocher D.
GammaH2AX as a checkpoint maintenance signal.
Cell Cycle. 2006 Jul;5(13):1376-81. Epub 2006 Jul 1.
PubMed abstract
Blake D, Luke B, Kanellis P, Jorgensen P, Goh T, Penfold S, Breitkreutz BJ, Durocher D, Peter M, Tyers M.
The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae.
Genetics. 2006 Jun 4.
PubMed abstract | Text on genetics.org
Kolas NK, Durocher D.
DNA repair: DNA polymerase zeta and Rev1 break in.
Curr Biol. 2006 Apr 18;16(8):R296-9.
PubMed abstract
Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D.
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.
Cell. 2006 Mar 24;124(6):1155-68.
PubMed abstract
Downey M, Durocher D.
Chromatin and DNA repair: the benefits of relaxation.
Nat Cell Biol. 2006 Jan;8(1):9-10.
Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ.
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.
Nature. 2006 Jan 26;439(7075):497-501. Epub 2005 Nov 20.
PubMed abstract
2005
Sweeney FD, Yang F, Chi A, Shabanowitz J, Hunt DF, Durocher D.
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.
Curr Biol. 2005 Aug 9;15(15):1364-75.
PubMed abstract
Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, Gray MW, Harrington LA, Hieter PA, Johnston G, Kelvin DJ, McCarry BE, Michnick SW, Ouellette F, Pearlman RE, Penn LJ, Pelletier J, Rachubinski RA, Rennie PS, Rotin D, Rottapel R, Sadowski I, Sicheri F, Siminovitch L, Sonenberg N, Siu KW, Tremblay ML, Winegarden N, Wozniak RW, Wright GD, Woodgett JR.
Problems with co-funding in Canada.
Science. 2005 Jun 24;308(5730):1867.
Bernstein NK, Williams RS, Rakovszky ML, Cui D, Green R, Karimi-Busheri F, Mani RS, Galicia S, Koch CA, Cass CE, Durocher D, Weinfeld M, Glover JN.
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Mol Cell. 2005 Mar 4;17(5):657-70.
PubMed abstract
2004
Koch CA, Agyei R, Galicia S, Metalnikov P, O'Donnell P, Starostine A, Weinfeld M, Durocher D.
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.
EMBO J. 2004 Oct 1;23(19):3874-85. Epub 2004 Sep 23.
PubMed abstract | Text on PubMed Central
2003
Kanellis P, Agyei R, Durocher D.
Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability.
Curr Biol. 2003 Sep 16;13(18):1583-95.
PubMed abstract
Durocher D, Smerdon SJ, Yaffe MB, Jackson SP.
The FHA domain in DNA repair and checkpoint signaling.
Cold Spring Harb Symp Quant Biol. 2000;65:423-31. Review.
Durocher D.
Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction.
Trends Microbiol. 2003 Feb;11(2):67-8.
2002
Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ.
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
Mol Cell. 2002 May;9(5):1045-54.
PubMed abstract
Durocher D, Jackson SP. Related Articles, Links
Abstract
The FHA domain.
FEBS Lett. 2002 Feb 20;513(1):58-66. Review.
PubMed abstract
Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, Adams SL, Millar A, Taylor P, Bennett K, Boutilier K, Yang L, Wolting C, Donaldson I, Schandorff S, Shewnarane J, Vo M, Taggart J, Goudreault M, Muskat B, Alfarano C, Dewar D, Lin Z, Michalickova K, Willems AR, Sassi H, Nielsen PA, Rasmussen KJ, Andersen JR, Johansen LE, Hansen LH, Jespersen H, Podtelejnikov A, Nielsen E, Crawford J, Poulsen V, Sorensen BD, Matthiesen J, Hendrickson RC, Gleeson F, Pawson T, Moran MF, Durocher D, Mann M, Hogue CW, Figeys D, Tyers M.
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
Nature. 2002 Jan 10; 415(6868):180-3
PubMed abstract
2001
Durocher D and Jackson SP.
DNA-PK, ATM and ATR, variations on a theme?
Curr Opin Cell Biol . 2001 Apr 13 (2):225-31. Review.
PubMed abstract
2000
Durocher D., Yaffe MB and Jackson SP.
Regulation of DNA damage signalling by FHA domains.
Cold Spring Harbor Symposia on Quantitative Biology (2000) Review.
Durocher D, Taylor IA, Sarbassova D, Haire LH, Westcott SL, Jackson SP, Smerdon SJ and Yaffe MB.
The molecular basis of FHA domain: phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Molecular Cell. 2000, 6:1169-1182
PubMed abstract | Text on molecule.org
1999
Durocher D, Henckel J, Fersht A, Jackson SP.
The FHA domain is a modular phosphopeptide recognition motif.
Molecular Cell. 1999, 4:387-394
PubMed abstract | Text on molecule.org