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Dr. H. McNeill Lab



Published Refereed Papers: (Click Here for full PubMed listing)










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Relevant Earlier Publications


  1. The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila. 
    Chang YJ, Zhou L, Binari R, Manoukian A, Mak T, McNeill H, Stambolic V.
    PLoS One (2016)

  2. Regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein.
    Payankaulam S, Yeung K, McNeill H, Henry RW, Arnosti DN.
    Scientific Reports (2016)

  3. FAT1 mutations cause a glomerulotubular nephropathy. 
    Gee HY, Sadowski CE, Aggarwal PK, Porath JD, Yakulov TA, Schueler M, Lovric S, Ashraf S, Braun DA, Halbritter J, Fang H, Airik R, Vega-Warner V, Cho KJ, Chan TA, Morris LG, Ffrench-Constant C, Allen N, McNeill H, Büscher R, Kyrieleis H, Wallot M, Gaspert A, Kistler T, Milford DV, Saleem MA, Keng WT, Alexander SI, Valentini RP, Licht C, Teh JC, Bogdanovic R, Koziell A, Bierzynska A, Soliman NA, Otto EA, Lifton RP, Holzman LB, Sibinga NE, Walz G, Tufro A, Hildebrandt F. 
    Nature Communications (2016)

  4. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.
    Chiu CW, Monat C, Robitaille M, Lacomme M, Daulat AM, Macleod G, McNeill H, Cayouette M, Angers S.
    Developmental Cell (2016)

  5. Yap and Taz are required for Ret-dependent urinary tract morphogenesis.
    Reginensi A, Hoshi M, Boualia SK, Bouchard M, Jain S, McNeill H.
    Development (2015)

  6. Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.
    Badouel C, Zander M, Liscio N, Bagherie-Lachidan M, Sopko R, Coyaud E, Raught B, Miller F, McNeill H. 
    Development (2015)

  7. Stromal Fat4 acts non-autonomously with Dachsous1/2 to restrict the nephron progenitor pool.
    Bagherie-Lachidan M, Reginensi A, Zaveri HP, Scott DA, Helmbacher F, McNeill H. 
    Development (2015)

  8. Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.
    Sugiyama Y, Shelley EJ, Badouel C, McNeill H, McAvoy JW.  
    Investigating Ophthalmology and Visual Science (2015)

  9. Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure.
    Schwartzman M, Reginensi A, Wong JS, Basgen JM, Meliambro K, Nicholas SB, D'Agati V, McNeill H, Campbell KN. 
    Journal of American Society of Nephrology (2015)

  10. The atypical cadherin fat directly regulates mitochondrial function and metabolic state.
    Sing A, Tsatskis Y, Fabian L, Hester I, Rosenfeld R, Serricchio M, Yau N, Bietenhader M, Shanbhag R, Jurisicova A, Brill JA, McQuibban GA, McNeill H.
    Cell (2014)

  11. Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control.
    Avet-Rochex A, Carvajal N, Christoforou CP, Yeung K, Maierbrugger KT, Hobbs C, Lalli G, Cagin U, Plachot C, McNeill H, Bateman JM.
    PLoS Genetics (2014)

  12. Regulation of neuronal migration by Dchs1-Fat4 planar cell polarity.
    Zakaria S, Mao Y, Kuta A, Ferreira de Sousa C, Gaufo GO, McNeill H, Hindges R, Guthrie S, Irvine KD, Francis-West PH.
    Current Biology (2014)

  13. In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle.
    Belozerov VE, Ratkovic S, McNeill H, Hilliker AJ, McDermott JC.  
    Molecular Cell Biology (2014)

  14. Hippo gains weight: added insights and complexity to pathway control. Enderle L, McNeill H.
    Science Signaling (2013)

  15. Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development.
    Cappello S, Gray MJ, Badouel C, Lange S, Einsiedler M, Srour M, Chitayat D, Hamdan FF, Jenkins ZA, Morgan T, Preitner N, Uster T, Thomas J, Shannon P, Morrison V, Di Donato N, Van Maldergem L, Neuhann T, Newbury-Ecob R, Swinkells M, Terhal P, Wilson LC, Zwijnenburg PJ, Sutherland-Smith AJ, Black MA, Markie D, Michaud JL, Simpson MA, Mansour S, McNeill H, Götz M, Robertson SP.
    Nature Genetics (2013)

  16. Organizer formation in Hydra is disrupted by thalidomide treatment.Brooun M, Manoukian A, Shimizu H, Bode HR, McNeill H.
    Developmental Biology (2013)

  17. Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. 
    Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H. 
    PLoS Genet. (2013)

  18. Regulation of long-range planar cell polarity by Fat-Dachsous signaling.
    Sharma P, McNeill H
    Development (2013)

  19. Fat and Dachsous Cadherins. 
    Sharma P, McNeill H
    Progress in Molecular Biology and Translational Science (2013)

  20. Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain. 
    Avet-Rochex A, Kaul AK, Gatt AP, McNeill H, Bateman JM.  

  21. Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.
    Saburi S, Hester I, Goodrich L, McNeill H. 
    Development (2012)

  22. Mink1 regulates beta-catenin-independent Wnt signaling via Prickle phosphorylation.
    Daulat AM, Luu O, Sing A, Zhang L, Wrana JL, McNeill H, Winklbauer R, Angers S. 
    Molecular Cell Biology (2012)

  23. The Hippo tumorsuppressor pathway: a report on 'the Second Workshop On The Hippo tumor suppressor pathway'.
    McNeill H, Sudol M, Halder G, Strano S, Blandino G, Shaul Y.  
    Cell Death and Differentiation

  24. SnapShot: The hippo signaling pathway.
    Badouel C, McNeill H.

  25. Role of elongator subunit Elp3 in Drosophila melanogaster larval development and immunity.
    Walker J, Kwon SY, Badenhorst P, East P, McNeill H, Svejstrup JQ.

  26. When pathways collide: collaboration and connivance among signalling proteins in development. 
    McNeill H, Woodgett JR. 
    Nature Reviews Molecular Cell Biology (2010)

  27. The Hippo pathway regulates Wnt/beta-catenin signaling.
    Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R,Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L. 
    Developmental Cell (2010)

  28. Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown.
    Sopko R, Silva E, Clayton L, Gardano L, Barrios-Rodiles M, Wrana J, Varelas X, Arbouzova NI, Shaw S, Saburi S, Matakatsu H, Blair S, McNeill H.
    Current Biology (2009)

  29. LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.
    Amin N, Khan A, St Johnston D, Tomlinson I, Martin S, Brenman J, McNeill H.
    Proceedings of the National Academy of Sciences USA (2009)

  30. The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie.
    Badouel C, Gardano L, Amin N, Garg A, Rosenfeld R, Le Bihan T, McNeill H.  
    Developmental Cell (2009)

  31. Visualization of PCP defects in the eye and wing of Drosophila melanogaster.
    Arbouzova N, Mcneill H.
    Methods in Molecular Biology (2009)

  32. Apical junctions and growth control in Drosophila.
    Badouel C, McNeill H.  
    Biochim Biophys Acta. (2009)

  33. Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.
    Saburi S, Hester I, Fischer, E., Pontoglio M, Eremina V, Gessler M, Quaggin SE, Harrison R, Mount R, and McNeill H.
    Nature Genetics (2008)

  34. Regulation of neurogenesis and epidermal growth factor receptor signaling by the insulin receptor/target of rapamycin pathway in Drosophila.
    McNeill H, Craig GM, and Bateman JM.  
    Genetics (2008)

  35. The tumour suppressor gene fat controls tissue growth upstream of Expanded in the Hippo signalling pathway.
    Silva E, Gardano L, Tapon N, and McNeill H.
    Current Biology (2006)

  36. Insulin/IGF signalling in neurogenesis.
    Bateman JM, McNeill H.
    Cell Molecular Life Sciences (2006)

  37. Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo.
    Bilioni A, Craig G, Hill C & McNeill H.
    Proceedings of the National Academy of Sciences USA (2005)

  38. Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity. 
    Saburi S and McNeill H.  
    Current Opinions in Cell Biology (2005)

  39. The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II. 
    Srinivasan S, Armstrong J, Dahlsveen I, McNeill H & Tamkun, J.
    Development (2005)

  40. Determining Organ and Organism size. 
    Leevers S and McNeill H
    Current Opinions in Cell Biology (2005)

  41. Temporal control of differentiation by the Insulin receptor/Tor pathway in Drosophila.
    Bateman, J. M. & McNeill, H.
    Cell (2004)

  42. Planar Polarity: from flies to vertebrates. 
    Fanto, M. and McNeill, H.  
    Journal of Cell Science (2004)

  43. The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.
    Fanto M, Clayton L, Meredith J, Hardiman K, Kerridge S, McNeill H.  
    Development (2003)

  44. Fidelity in planar cell polarity signalling.
    Ma D, Yang CH, McNeill H, Simon MA, Axelrod JD.
    Nature (2003)

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Relevant Earlier Publications

  1. Jordan KC, Clegg NJ, Blasi JA, Morimoto AM, Sen J, Stein D, McNeill H,Deng WM, Tworoger M, Ruohola-Baker H. The homeobox gene mirror links EGF signalling to embryonic dorso-ventral axis formation through Notch activation. Nature Genet. (2000) 24(4):429-33.

  2. Yang CH, Simon MA, McNeill, H. Mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. Development. (1999) 126(24):5857-66.

  3. McNeill, H., Yang, C., Brodsky, M., Ungos, J., and Simon, M.A. Mirror encodes a novel PBX-Class Homeoprotein that Defines the D/V Border in the Eye. Genes & Dev. (1997) 11(8):1073-1081.