Cre transgenic database

UNDER DEVELOPMENT

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Status: *planned*

Promoter - (linked to additional information)

Specificity

Status

Last Updated

bHLH-EC2 Mesoderm at 7.5 days. Later restricted to precursor cells in dermamyotome & blood islands Suggested Apr 10/97
Hoxa-1 Neuroectoderm and mesoderm Being made Apr 10/97
AFP promoter/enhancer Visceral endoderm yolk sac, fetal gut and fetal liver, off after birth Suggested Apr 10/97
rat neuron-specific enolase In post-mitotic neurons, starts at E12, reaching constant levels at E18 (variable levels in different areas) Made, so far systemic recombination Apr 22/97
m sucrase-isomaltase small intestine is being made Nov /99
osteocalcin bone is being made Aug /99
opsin Rod photoreceptors is being made Jun 26/99
T cell receptor LCR Begins day 15.5 p.c. in thymus in alpha-beta T cells Suggested Apr 10/97
MMTVD LTR Immature T cells (not in mature CD4+CD8- or CD4-CD8+ cells) Suggested Apr 10/97
human Fc-gamma-RI Monocyte/macrophage specific cytokine regulated (up and down) Planned to be made Apr 10/97
CR1/2 FDCs, B cells is being made Aug /99
alpha A-crystallin Expressed in differentiating lens fiber cells Suggested Apr 10/97
human insulin promoter Beta cells in adult pancreas of transgenic mice, and in embryonic pancreas (day 9.5 pc -->) Suggested Apr 10/97
Pdha-2 Spermatogenic cell (initially in leptotene with significant expression in pachytene spermatocytes). Unpublished studies show only 187 nts of the promoter necessary for tissue and temporal specific activity Suggested May 15/97
HCF1 (host cell factor) Ubiquitous Suggested Apr 21/97

 


Hoxa-1

Contact: Osamu Chisaka and Masatoshi Takeichi

Email: ochisaka@take.biophys.kyoto-u.ac.jp

Reference for promoter:

Reference for Cre transgenic line:

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AFP promoter/enhancer

Contact: Shirley Tilghman

Email: stilghman@molbiol.princeton.edu

References for promoter: Hammer (1987) Science 235: 53-58

Camper (1989) Genes Dev. 3: 537-546

Reference for Cre transgenic line:

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Rat neuron-specific enolase

Contact: Hans Thoenen/M. Meyer

Fax: 49-89-856-1121

Reference for promoter: Forss-Petter (1990) Neuron 5: 187-197

Reference for Cre transgenic line:

 

Contact: Jamey D. Marth

Email: jmarth@ucsd.edu

Reference for promoter: Forrs-Petter (1990) Neuron 5: 187-197

Status: Made, activity detected in early development resulting in systematic recombination

Reference for Cre transgenic line:

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mouse sucrase-isomaltase

Contact:David B. Rhoads

Email: drhoads@partners.org

Reference for promoter: Markowitz et al, Am J. Physiol 269\: G925

Status: is being made,

Reference for Cre transgenic line:

Comments: Cre driven by both -8500 to +54 and -201 to +54 promoters is being constructed.

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Osteocalcine

Contact: David Thomas

Email: dthomas@hms.harvard.edu

Reference for promoter:

Status: is being made,

Reference for Cre transgenic line:

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Opsin

Contact: Stephen Tsang

Email: sht2@columbia.edu

Reference for promoter: Opsin

Reference for Cre transgenic line:

Expression: Rod photoreceptors

Status: is being made

Comments:


T cell receptor LCR

Contact: Dragana Cado

Email: dragana@uclink4.berkeley.edu

Reference for promoter: Diaz (1994) Immunity 1: 207

Reference for Cre transgenic line:

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MMTVD LTR

Contact: Paul Jolicoeur

Email: jolicop@ircm.umontreal.ca

Reference for promoter: Paquette, Mol. Cell. Biol. 12: 3522-3530

Reference for Cre transgenic line:

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Human Fc-gamma-RI

Contact: J.S. Verbeek

Email: j.s.verbeek@pobox.ruu.nl

Reference for promoter:

Reference for Cre transgenic line:

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Alpha A-crystallin

Contact: Jaspal S. Khillan

Email: khillan@hendrix.jci.tju.edu

Reference for promoter: Overbeek (1985) PNAS 82: 9123-9127

Reference for Cre transgenic line:

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Human insulin

Contact: Jacques Jami

Email: jami@cochin.inserm.fr

Reference for promoter: Fromont-Racine (1990) Mol.Endocrinol. 4: 669-677

Reference for Cre transgenic line:

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Pdha-2

Contact: Rocco Iannello

Email: rocciann@silas.cc.monash.edu.au

Reference for promoter: Iannello et al. (1993) J.Biol.Chem. 268: 22581-22590

Reference for Cre transgenic line:

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HCF1 (host cell factor)

Contact: Paolo Vezzoni

Email: vezzoni@itba.mi.cnr.it

Reference for promoter: Frattini et al, Genomics (in press)

Reference for Cre transgenic line:

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