UNDER DEVELOPMENT
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Status: made, not characterized
|
Promoter - (linked to additional information) |
Specificity |
Status |
Last Updated |
| HNF3-alpha | Day 7.5 embryonic endoderm; day 8.5 foregut & hindgut endoderm; weak in notochord. After day 8.75: notochord, endoderm-derived tissues; ventral parts of midbrain | Made, not tested yet. | Oct 28/97 |
| Nestin | Neuronal precursor cells, highest E-12 embryo and declines after | Made, not tested | May 29/97 |
| Synapsin | Neurons (brain and spinal cord), maximum around 18 days old | Made, being tested | Apr 10/97 |
| Glial fibrillary acidic protein (GFAP) | Astrocytes | Made, tested positive for expression, not tested for excision | Apr 10/97 |
| CDllb | Peritoneal macrophages, blood and bone marrow monocytes | Made, not tested | Apr 10/97 |
| E-mu Ig promoter-Sv40 enhancer | B lymphopoiesis ~ fetal day 12 | Made, being tested | Apr 22/97 |
| GATA-1 | In multipotential progenitor cells and selected hematopoietic lineages (erythroid, megakaryocytic, and mast cell) | Made, being tested | Apr 10/97 |
| alpha1-antitrypsin | hepatocytes | Made, being tested | May 3/99 |
| Tyrosinase enhancer/promoter | Pigmented cells (melanin), melanocytes, choroid, retinal pigmented epithelium | Made, not tested | Apr 10/97 |
| tek (tie-2) | Endothelial cells from fetal day 8.5 | Made, being tested | Apr 22/97 |
| KAP | Renal Proximal Tubule Cells | Made, being tested | Apr 28/99 |
| K6 (keratin promoter) | Hair follicles and suprabasal cells of a variety of internal stratified epithelia; induced in epidermis in both natural and artificially caused hyperproliferative situations | Made, not tested | Apr 10/97 |
| MMTV | Mammary epithelium, but also in the epithelial cells of the lung, kidney, prostate, salivary and testis | Made, being tested | Apr 10/97 |
| Pgk-2 | Commences in spermatocytes, strong expression in spermatids | Made, being tested | May 12/98 |
| SP-C, SP-A, SP-B, TTF-1, CC10 | Lung epithelium | Made, being tested | Apr 21/97 |
| Actin | General deletor | Made, being tested, Link | Aug 22/99 |
| tet-0- (CMV minimal and tet operators) | Component of tetracycline inducible system | Made, not tested | Apr 10/97 |
Contact: Klaus H. Kastner
Fax: 49-6221-423470
References for promoter: Kaestner (1994) Genomics 20: 377-385
Monaghan (1993) Development 119: 567-578
Reference for Cre transgenic line:
Contact: Shigeo Okabe
Fax: 301-402-1340
Reference for promoter: Neuron 12:11-24 (1994)
Reference for Cre transgenic line:
Contact: Jamey D. Marth
Email: jmarth@ucsd.edu
Reference for promoter: Hoesche (1993) J.Biol.Chem. 268: 26494-26502
Reference for Cre transgenic line:
Glial fibrillary acidic protein (GFAP)
Contact: Albee Messing
Email: amessing@svm.vetmed.wisc.edu
Reference for promoter:
Status:
Reference for Cre transgenic line:
Contact: Robert A. Lazzarini
Fax: 212-860-9279
Reference for promoter: Toggas (1994) Nature 367:188
Reference for Cre transgenic line:
Contact: Dan Tenen
Email: tenen@mbcrr.harvard.edu
Reference for promoter: HL Pahl, 33nd Annual Mtg of Am Soc of Hematology, Denver, Dec '91 (Blood 78:373a, 1991)
Reference for Cre transgenic line:
E-mu Ig promoter-Sv40 enhancer
Contact: Jamey D. Marth
Email: jmarth@ucsd.edu
Reference for promoter:
Reference for Cre transgenic line:
Contact: Stuart Orkin
Email: orkin@rascal.med.harvard.edu
Reference for promoter:
Reference for Cre transgenic line:
Contact: Curt D. Sigmund, Ph.D.
Email: curt-sigmund@uiowa.edu
Reference for promoter:
Status: Transgenic line made, being tested
Reference for Cre transgenic line:
Contact: Graham Kay
Email: grahamk@qimr.edu.au
Reference for promoter: Beerman, Nucleic Acids Res.19: 958
Status: Transgenic line made, not tested
Reference for Cre transgenic line:
Update: Apr 10/97
Contact: Lionel Larue/Veronique Delmas
Email: lionel.larue@curie.fr
References for promoter: Ruppert (1988) EMBO J. 7: 2715
Bradl (1991) PNAS 88: 164-168
Porter (1994) Development 120: 2103-2111
Status: Transgenic line will be made
Reference for Cre transgenic line:
Update: Apr 10/97
Contact: Jamey D. Marth
Email: jmarth@ucsd.edu
Reference for promoter: Dumont, Genes Dev. 8: 1897-1909
Reference for Cre transgenic line:
KAP Kidney-Androgen Regulated Protein Pr
Contact: Curt D. Sigmund, Ph.D.
Email: curt-sigmund@uiowa.edu
Reference for promoter: J.Biol.Chem. 272\: 28142-28148, 1997
Reference for Cre transgenic line:
Comments: Expression: Renal Proximal Tubule Cells
Status: Made, currently testing for expression
Contact: Janet Sawicki
Email: sawicki@voicenet.com
Reference for promoter: Handbook of Mouse Mutations with Skin and Hair Abnormalities (1994), Chapter 9
Status: Transgenic line made, not tested
Reference for Cre transgenic line:
Contact: Delmas/Larue/Kemler; Robert Moore
Email: lionel.larue@curie.fr
References for promoter: moore@immunbio.mpg.de
Fasel (1982) EMBO J. 1: 3-7
Status: Transgenic line made; being tested
Reference for Cre transgenic line:
Updated: Apr 10/97
Contact: Paul Jolicoeur
Email: jolicop@ircm.umontreal.ca
Reference for promoter: Bouchard (1989) Cell 57: 931
Status: Transgenic line suggested
Reference for Cre transgenic line:
Updated: Apr 10/97
Contact: Dr. Frans van der Hoorn, Dr. S. Tilhman
Email: fvdhoorn@acs.ucalgary.ca
Reference for promoter: Robinson et al. (1989) Proc.Natl.Acad.Sci.USA 86: 8437-8441
Reference for Cre transgenic line:
Expression: spermatocytes, spermatids
Status: made/being tested for expression
Comments: Currently being tested for specificity in expression/excision. Allows for study of meiotic specific genes in male gametogenesis and to generate whole animal knockout via sperm specific deletion.
Contact: Bob Erickson
Email: rpe20@mole.bio.cam.ac.uk
Reference for promoter: Robinson et al. (1989) Proc.Natl.Acad.Sci.USA 86: 8437-8441
Reference for Cre transgenic line:
Status: suggested
Contact: Jeff Whitsett
Fax: 513-559-7868
References for promoter: Korfhagen (1990) PNAS 87:6122
Glasser (1991) Am. J. Phys. 261: 349
Wert (1993) Dev. Biol. 156: 426
Stripp (1992) J. Biol. Chem. 267: 14703
Bohinski (1993) J. Biol. Chem. 268: 11160
Reference for Cre transgenic line:
SP-C
Contact: Jamey D. Marth
Email: jmarth@ucsd.edu
Reference for promoter: Korfhagen (1990) PNAS 87: 6122
Status: Made, being characterized
Reference for Cre transgenic line:
Contact: George Kassiotis
Email: george_kassiotis@hotmail.com
Reference for promoter: Actin
Reference for Cre trangenic line:
Status: Generic
Comments: http://www.pasteur.gr/molgen/animal_resources.htm
tet-0- (CMV minimal and tet operators)
Contact: Bruno Giros
Email: giros@im3.inserm.fr
Reference for promoter: tet-O-
Reference for Cre transgenic line:
Notes: We have injected the following construct\: tetO\>rtTA--Cre\tetO, i.e. both rtTA and Cre are under the control of tetO. We speculated that a light leakage of the promoter will be enough to "prime" the enhancement following Dox administration. We also add NRSF sites following the two promoter sites to try to reach a certain specificity of expression in the brain. 6 lines have been obtained, and are currently under investigation.
tet-0- (CMV minimal and tet operators)
Contact: Andras Nagy
Email: nagy@mshri.on.ca
Reference for promoter: tet-O-
Reference for Cre transgenic line:
Notes: Made in collaboration with Glenn Fishman - not teted yet, but sent out for testing and use to
Tracey A. Lodie, Ph.D: email: <lodie@sprcore.bidmc.harvard.edu>