For the most recent publication listing, please visit the PubMed lab listing

Murphy JM, Korzhnev DM, Ceccarelli DF, Briant DJ, Zarrine-Afsar A, Sicheri F, Kay LE, Pawson T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. (2007) Proc Natl Acad Sci, 104,14336-41.

Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD. Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain. (2007) Cell, 30, 651-62.

Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli DF,  Mercurio F, Shilton BH, Sicheri F*, Tyers M. Suprafacial orientation of the SCF^Cdc4 dimer accommodates multiple geometries for substrate ubiquitination. (2007) Cell, 129, 1165-1176.

Ceccarelli DFJ, Blasutig I, Goudreault M, Li Z, Ruston J, Pawson T, Sicheri F. Non-canonical interaction of phosphoinositides with the pleckstrin homology domains of Tiam1 and ArhGAP9. (2007) J Biol Chem. 282, 13864-74.

Dey M, Cao C, Sicheri F, Dever TE. Conserved intermolecular salt-bridge required for activation of protein kinases PKR, GCN2 and PERK. (2007) J Biol Chem, 282, 6653-60.

Leung GC, Ho CS, Blasutig IM, Murphy JM, Sicheri F. Determination of the Plk4/Sak consensus phosphorylation motif using peptide spots arrays. (2007) FEBS Lett., 581, 77-83.      

Wiesner S, Wybenga-Groot LE, Warner N, Lin H, Pawson T, Forman-Kay JD, Sicheri F. A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. (2006) EMBO J., 25, 4686-4696.  

Mrkobrada S, Boucher L, Ceccarelli DF, Tyers M, Sicheri F. Structural and Functional Analysis of Saccharomyces cerevisiae Mob1. (2006) J Mol Biol, 36, 430-440.

Aviv T, Lin Z, Ben-Ari G, Smibert CA, Sicheri F. Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p. (2006) Nat Struct Mol Biol, 13, 168-176.

Aviv T, Amborski AN, Zhao XS, Kwan JJ, Johnson PE, Sicheri F*, Donaldson IW. The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpins. (2005) J Mol Biol, 356, 274-279.

Dar AC, Dever TE, Sicheri F. Higher-order substrate recognition of eIF2α by the RNA-dependent protein kinase PKR. (2005) Cell, 122, 887-900.

Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE.  Mechanistic link between PKR dimerization, autophosphorylation, and eIF2α substrate recognition. (2005) Cell, 122, 901-913.

Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F*, Wrana JL. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. (2005). Mol Cell, 19, 297-308.

Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F*, Dever TE.  PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2α. (2005) Mol Cell Biol, 25, 3063-3075.

Zigmond SH, Evangelista M, Boone C, Yang C, Dar AC, Sicheri F, Forkey J, Pring M. Formin leaky cap allows elongation in the presence of tight capping proteins. (2003) Curr Biol, 13, 1820-1823.

Hoang QQ, Sicheri F, Howard AJ, Yang DS. Bone recognition mechanism of porcine osteocalcin from crystal structure, (2003) Nature, 425, 977-980.

Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F*, Smibert CA. The RNA-binding SAM domain of smaug defines a new family of post-transcriptional regulators. (2003) Nat Struct Biol, 10, 614-621.

Orlicky S, Tang X, Willems A, Tyers M, Sicheri F. Structural basis for phosphodependent substrate selection and orientation by the SCF (Cdc4) ubiquitin ligase. (2003) Cell, 112, 243-256.

Leung GC, Hudson JW, Kozarova A, Davidson A, Dennis JW, Sicheri F.  The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. (2002) Nat Struct Biol,  9, 719-724.

Dar A, Sicheri, F. X-Ray Crystal Structure and Functional Analysis of Vaccinia Virus K3L Reveals Molecular Determinants for PKR Subversion and Substrate Recognition. (2002) Mol Cell, 10, 295-305.

Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M.  Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. (2001) Nature, 414, 514-521.

Luo Y, Bertero MG, Frey EA, Pfuetzner RA, Wenk MR, Creagh L, Marcus SL, Lim D, Sicheri F, Kay C, Haynes C, Finlay BB, Strynadka NC.  Structural and biochemical characterization of the type III secretion chaperones CesT and SigE. (2001) Nat Struct Biol, 12, 1031-1036.

Wybenga-Groot LE, Baskin B, Pawson T, Sicheri F. Structural basis for autoinhibition of the EphB2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. (2001) Cell, 106, 745-757.

Ezelle HJ, Balachandran S, Sicheri F, Polyak SJ, Barber GN. Analyzing the mechanisms of interferon-induced apoptosis using CRMa and hepatitis c virus NS5A. (2000) Virology, 281, 124-137.

Binns KL, Taylor PP, Sicheri F, Pawson T, Holland SJ.  Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors. (2000) Mol Cell Biol, 20, 4791-4805.

Schindler T, Sicheri F, Pico A, Gazit A, Levitzki A, Kuriyan J. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. (1999) Mol Cell, 5, 639-648.

Stapleton D, Balan I, Pawson T, Sicheri F. The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization. (1999) Nature Structural Biology, 1, 44-49.

LaFevre-Bernt M, Sicheri F, Pico A, Porter M, Kuriyan J, Miller WT. Intramolecular Regulatory Interactions in the Src Family Kinase Hck Probed by Mutagenesis of a Conserved Tryptophan Residue. (1998) J Biol Chem, 273, 32129-32134.

Yang, DS-C, Hon W-C, Bubanko S, Xue Y, Seetharaman J, Hue CL, Sicheri, F.  Identification of the ice binding surface on a type III AFP with a ‘flatness function’ algorithm. (1998) Biophys J, 74, 2142-2151.

Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. (1997) Nature, 385, 602-610.

Moarefi H, LaFevre-Bernt M, Sicheri F, Huse M, Lee C-H, Kuriyan J, Miller WT.  Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. (1997)  Nature, 385, 650-653.

Asante-Appiah E, Seetharaman J, Sicheri F, Yang DS-C, Chan WWC. Gem-dialkyl succinic acids: A novel class of inhibitors for carboxypeptidases. (1997) Biochemistry, 36, 8710-8715.

Sicheri F, Yang DS-C. Structure determination of an a-helical antifreeze protein from winter flounder. (1996) Acta Cryst, D52, 486-498.

Sicheri F, Yang, DS-C.  Ice binding structure and mechanism of an antifreeze protein from winter flounder. (1995) Nature, 375, 427-431

Xue YQ, Sicheri F, Ala P, Hew CL, Yang, DS-C. Single Crystals of a Type III  Antifreeze Polypeptide from Ocean Pout. (1994) J Mol Biol,  237, 351-352.

Sicheri F, Derry WB, Gupta RS, Yang DS-C. Crystal Structure of 5-[1-(4'-methoxyphenyl) ethyl]-6-ethox1-9-ol)-1,3-benzodioxole. (1992) Acta Cryst, C48, 1687-1689.

Sicheri F, Derry WB, Gupta RS, Yang, DS-C. Crystal Structure of 4'-Demethylepipodophyllotoxin. (1992) Acta Cryst, C48, 747-749.