For the most recent publication listing, please visit PubMed

Selected publications:

Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M. A dimerization-dependent allosteric mechanism drives RAF catalytic activation. (2009) Nature, 461, 542-5.

Mao DYL, Neculai D, Downey M, Orlicky S, Haffani Y, Ceccarelli DF, Ho JSL, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Durocher D, Sicheri F. Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. (2008) Molecular Cell, 32, 259-75.  

Rajakulendran T, Sahmi M, Kourinov I, Tyers M, Therrien M, Sicheri F. CNK and HYP form a discrete dimer via their SAM domains to mediate RAF kinase signaling. (2008) Proc Natl Acad Sci, 105, 2836-41.

Kurz T, Chou Y-C, Willems A, Meyer-Schaller N, Hecht M-L, Tyers M, Peter M, Sicheri F. Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation (2008) Molecular Cell, 29, 23-35.  

Lee K, Dey M, Neculai D, Cao C, Dever TE, Sicheri F. Structure of the Dual Enzyme Ire1 Reveals the Basis of Catalysis and Regulation in Nonconventional RNA Splicing. (2008) Cell, 132, 89-100.

Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD. Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain. (2007) Cell, 30, 651-62.  

Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli DF,  Mercurio F, Shilton BH, Sicheri F, Tyers M. Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. (2007) Cell, 129, 1165-1176.

Ceccarelli DFJ, Blasutig I, Goudreault M, Li Z, Ruston J, Pawson T, Sicheri F. Non-canonical interaction of phosphoinositides with the pleckstrin homology domains of Tiam1 and ArhGAP9. (2007) J Biol Chem. 282, 13864-74. 

Wiesner S, Wybenga-Groot LE, Warner N, Lin H, Pawson T, Forman-Kay JD, Sicheri F. A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. (2006) EMBO J., 25, 4686-4696.  

Aviv T, Lin Z, Ben-Ari G, Smibert CA, Sicheri F. Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p. (2006) Nat Struct Mol Biol, 13, 168-176.    

Dar AC, Dever TE, Sicheri F. Higher-order substrate recognition of eIF2α by the RNA-dependent protein kinase PKR. (2005) Cell, 122, 887-900.

Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE.  Mechanistic link between PKR dimerization, autophosphorylation, and eIF2α substrate recognition. (2005) Cell, 122, 901-913.

Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. (2005). Mol Cell, 19, 297-308.  

Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F, Dever TE.  PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2α. (2005) Mol Cell Biol, 25, 3063-3075.

Hoang QQ, Sicheri F, Howard AJ, Yang DS. Bone recognition mechanism of porcine osteocalcin from crystal structure, (2003) Nature, 425, 977-980.  

Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F, Smibert CA. The RNA-binding SAM domain of smaug defines a new family of post-transcriptional regulators. (2003) Nat Struct Biol, 10, 614-621.

Orlicky S, Tang X, Willems A, Tyers M, Sicheri F. Structural basis for phosphodependent substrate selection and orientation by the SCF (Cdc4) ubiquitin ligase. (2003) Cell, 112, 243-256.  

Leung GC, Hudson JW, Kozarova A, Davidson A, Dennis JW, Sicheri F.  The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. (2002) Nat Struct Biol,  9, 719-724.

Dar A, Sicheri, F. X-Ray Crystal Structure and Functional Analysis of Vaccinia Virus K3L Reveals Molecular Determinants for PKR Subversion and Substrate Recognition. (2002) Mol Cell, 10,295-305.  

Wybenga-Groot LE, Baskin B, Pawson T, Sicheri F. Structural basis for autoinhibition of the EphB2 receptor tyrosinekinase by the unphosphorylated juxtamembrane region. (2001) Cell, 106, 745-757.

Stapleton D, Balan I, Pawson T, Sicheri F. The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization. (1999) Nature Structural Biology, 1, 44-49.  

Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. (1997) Nature, 385, 602-610.

Moarefi H, LaFevre-Bernt M, Sicheri F, Huse M, Lee C-H, Kuriyan J, Miller WT.  Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. (1997)  Nature, 385, 650-653.  

Sicheri F, Yang, DS-C.  Ice binding structure and mechanism of an antifreeze protein from winter flounder. (1995) Nature, 375, 427-431.