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     Publications
        2010

  1.  Kim, J.S.M., Hung, W., Narbonne, P., Roy, R., and Zhen M. (2010) C. elegans STRADα and SAD Cooperatively Regulate Neuronal Polarity and Synaptic Organization. Development (in press).

  2.  Po, M. and Zhen, M. (2010) PHR Proteins and Nervous System Development. Current Opinion in Neurobiology (in press).
 
        2009

  1.  Mok, C., Heon, E. and Zhen, M.(2009) Ciliopathy and Obesity. Clinical Genetics Nov 23. [Epub ahead of print]

  2. Calarco, J. A., Superina, S.,O’Hanlon, D., Skalska, U., Gabut, M., Pan, Q., Raj, B., Clarke, L., Gelinas, D., van der Kooy, D., Zhen, M., Ciruna, B. and Blencowe, B. G. (2009) A Neural-Specific SR Protein Activator of Alternative Splicing. Cell 138: 1-13.

  3. Yeh E, Kawano T, Ng S, Fetter R, Hung W, Wang Y, and Zhen M.(2009) Caenorhabditis elegans Innexins Regulate Active Zone Differentiation. Journal of Neuroscience 29(16):5207-17.   Read Article      

     

        2008
         

  1. Liewald, J. F., Brauner, M., Stephens, G. J., Bouhours, M., Schultheis C., Zhen, M. and Gottschalk, A. (2008) Optogenetic Analysis of Synaptic Function by Behavioural and Electrophysiological Parameteterization in Caenorhabditis elegans. Nature Method 5(10): 895-902.

  2. Kim, J.S.M., Lilley, B.N., Zhang, C., Shokat, K.M., Sanes, J.R. and Zhen, M. (2008) A Chemical-Genetic Strategy Reveals Distinct Temporal Requirements for SAD-1 Kinase in Neuronal Polarization and Synapse Formation. Neural Development 3(1):23

  3.  Li, C., Inglis, P. N., Leitch, C. C., Efimenko, E., Zaghoul, N. A., Mok, C. A., Davis, E. E., Bialas, N., Healey, M. P., Heon, E., Zhen, M., Swoboda, P., Katsanis, N. and Leroux, M. R. (2008) An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes. PLoS Genetics  4 (3): e1000044. Read Article

  4. Yeh, E., Ng, S., Zhang, M., Bouhours, M., Wang, Y., Hung, W., Melnik-Martinez, K., Li, M., Schafer, W. and Zhen, M. (2008) A Voltage-Gated Cation Channel-like Protein NCA-1/UNC-77 and a Novel Protein UNC-80 Regulate Synaptic Activity and Development in C. elegans. PLoS Biology 6(3) e55. Read Article

  5. Gao, M.X., Liao, E., Yu, B., Wang, Y., Zhen, M. and Derry, W.B. (2008) The SCFFSN-1 Ubiquitin Ligase Regulates p53-Dependent Apoptosis and Synaptogenesis in C. elegans. Cell Death and Differentiation15(6): 1054-1062

  6. Wang, W., Bouhours, M., Gracheva, E.O., Liao, E., Xu, K., Sengar, A., Xin, X., Roder, J., Boone, C., Richmond, J., Zhen, M. and Egan, S. (2008) ITSN-1 is Required for Efficient Vesicle Recycling and Endogenous Synaptic Activity at C. elegans Neuromuscular Junctions. Traffic9(5): 742–754.

  7. Kim, J.S.M. and Zhen, M. (2008): Protons as Intracellular Messengers. Cell 132: 21-22.

  8. Kim, J.S.M. and Zhen, M. (2008) Neuronal Polarity. Encyclopedia of Neuroscience, Springer-Verlag.   

     

        2007

  1. Hung, W., Hwang, C., Po, M. and Zhen, M. (2007) Neuronal Polarity is Regulated by a Direct Interaction between a Scaffolding Protein Neurabin and a Presynaptic SAD-1 Kinase in Caenorhabditis elegans. Development 134: 237-249.

     

        2006

  1. Patel, M., Lehrman, E., Poon, V., Crump, J.G., Zhen, M., Bargmann, C.I., and Shen, K. (2006) Hierarchical Assembly of Presynaptic Components in Defined C. elegans Synapses. Nature Neuroscience 9: 1488-1498.

  2. Wang, Y., Gracheva, E.O., Richmond, J., Kawano, T., Couto, J.M., Calarco, J., Vijayaratnam, V., Jin, Y. and Zhen, M. (2006) The C2H2 Zinc-Finger Protein SYD-9 is a Putative Post-Transcriptional Regulator for Synaptic Transmission. Proceedings in the National Academy of Science USA 103(27): 10450-10455. Read Article

  3. Bi, G.Q. et al. (2006) Recent Advances in Basic Neurosciences and Brain Disease: from Synapses to Behaviour. Molecular Pain: 2:38. Read Article

  4. Zhen, M. (2006) Presynaptic Differentiation. In Protein Trafficking in the Neuron. (A.J. Bean, Ed.) London: Elsevier Academic Press . Pages 75-96. 

     

        2005
  1. Yeh, E., Kawano, T., Weimer, R., Bessereau, J.L. and Zhen, M. (2005) Identifying Genes Involved in Synaptogenesis Using a Fluorescent Active Zone Marker in C. elegans. Journal of Neuroscience 25(15): 3833-3841.
 
   2004

  1. Liao, E., Hung, W., Abrams, B. and Zhen, M. (2004) An SCF-like Ubiquitin Ligase Complex that Controls Presynaptic Differentiation. Nature 430: 345-350.

  2. Zhen, M. and Jin. Y. (2004) Presynaptic Terminal Differentiation: Transport and Assembly. Current Opinion in Neurobiology 14(3): 280-287        

     

        2001
  1. Crump, J.C., Zhen, M., Jin, Y. and Bargmann, C.I. (2001) The SAD-1 Kinase Regulates Presynaptic Vesicle Clustering and Axon Termination. Neuron 29: 115-12.
 
        1993-2000

  1. Zhen, M., Huang, X., Bamber, B. and Jin, Y. (2000) Regulation of Presynaptic Terminal Organization by C. elegans RPM-1, a Putative Guanine Nucleotide Exchanger with a Ring-H2 Finger Domain. Neuron 26: 331-343.

  2. Zhen, M. and Jin, Y. (1999) The Liprin Protein SYD-2 Regulates the Differentiation of Presynaptic Termini in C. elegans. Nature 401: 371-37.

  3. Zhen, M., Schein, J.E., Baillie, D.L. and Candido, E.P.M. (1996) An Essential Ubiquitin-Conjugating Enzyme with Tissue and Developmental Specificity in the Nematode Caenorhabditis elegans. EMBO Journal 15: 3229-323. Read Article

  4.  Zhen, M., Heilein, R., Jones, D., Jentsch, S. and Candido, E.P.M. (1993) The ubc-2 Gene of Caenorhabditis elegans Encodes a Ubiqutin-Conjugating Enzyme Involved in Selective Protein Degradation. Molecular and Cellular Biology 13: 1371-1377. Read Article

 

 


C. elegans


FSN-1::GFP

Fluorescent markers are developed  to illuminate neuronal structures


Synapse mutants are identified under high magnification